HCID 10097475, compound → HCID 58905270, compound

HRID 1294385Notes

Reaction equation

HRID 1294385 reaction equation
CS[CH2:3][CH2:4][NH:5][C:6]([C:8]1[C:17](=[O:18])[C:16]2[C:11](=[N:12][CH:13]=[CH:14][CH:15]=2)[N:10]([C:19]2[CH:20]=[C:21]([C:25]3[CH:30]=[CH:29][C:28]([C@@H:31]4[CH2:33][C@H:32]4[C:34]([OH:36])=[O:35])=[CH:27][CH:26]=3)[CH:22]=[CH:23][CH:24]=2)[CH:9]=1)=[O:7].O[O:38][S:39]([O-:41])=O.[K+].[CH2:43]1COCC1.CO.O>O>[CH3:43][S:39]([CH2:3][CH2:4][NH:5][C:6]([C:8]1[C:17](=[O:18])[C:16]2[C:11](=[N:12][CH:13]=[CH:14][CH:15]=2)[N:10]([C:19]2[CH:20]=[C:21]([C:25]3[CH:26]=[CH:27][C:28]([CH:31]4[CH2:33][CH:32]4[C:34]([OH:36])=[O:35])=[CH:29][CH:30]=3)[CH:22]=[CH:23][CH:24]=2)[CH:9]=1)=[O:7])(=[O:41])=[O:38]

Participants

5

Reactant 3

HCID 10097475HCID 10097475, compoundHCID 21892291Methanol tetrahydrofuran waterHCID 23707502Potassium hydroxy sulfite

Product 1

HCID 58905270HCID 58905270, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of EXAMPLE 22 (1 eq) in THF-MeOH—H2O (2:1:1, 0.1M) was added Oxone (2 eq). The mixture was stirred at rt for 18 h and diluted with water. The residue was isolated by filtration, washed with ether to afford the title compound as a solid.

Workup

  1. customThe residue was isolated by filtration
  2. washwashed with ether

Sources & evidence

ORD record
ord-c4817dd892fb43f19b6f2f53c2e757ab
Source dataset
uspto-grants-2007_07
Patent number
US07238706B2

Reaction notes

Loading…