HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 10097475, compound → 2-{3'-[3-({[2-(Methylsulfonyl)ethyl]amino}carbonyl)-4-oxo-1,8-naphthyridin-1(4h)-yl]-1,1'-biphenyl-4-yl}cyclopropanecarboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 10097475 | HCID 10097475 | — |
| Reactant | Methanol tetrahydrofuran water | HCID 21892291 | — |
| Reactant | Potassium hydroxy sulfite | HCID 23707502 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-{3'-[3-({[2-(Methylsulfonyl)ethyl]amino}carbonyl)-4-oxo-1,8-naphthyridin-1(4h)-yl]-1,1'-biphenyl-4-yl}cyclopropanecarboxylic acid | HCID 58905270 | — |
Reaction Steps
To a solution of EXAMPLE 22 (1 eq) in THF-MeOH—H2O (2:1:1, 0.1M) was added Oxone (2 eq). The mixture was stirred at rt for 18 h and diluted with water. The residue was isolated by filtration, washed with ether to afford the title compound as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07238706B2 |
| Source dataset | uspto-grants-2007_07 |
| ORD ID | ord-c4817dd892fb43f19b6f2f53c2e757ab |
| Source note | uspto-grants-2007_07 |