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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1294385Generated: November 2, 2026

HCID 10097475, compound → 2-{3'-[3-({[2-(Methylsulfonyl)ethyl]amino}carbonyl)-4-oxo-1,8-naphthyridin-1(4h)-yl]-1,1'-biphenyl-4-yl}cyclopropanecarboxylic acid

https://huagongshe.com/reaction/1294385

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 10097475HCID 10097475—
ReactantMethanol tetrahydrofuran waterHCID 21892291—
ReactantPotassium hydroxy sulfiteHCID 23707502—
SolventWaterHCID 962—
Product2-{3'-[3-({[2-(Methylsulfonyl)ethyl]amino}carbonyl)-4-oxo-1,8-naphthyridin-1(4h)-yl]-1,1'-biphenyl-4-yl}cyclopropanecarboxylic acidHCID 58905270—

Reaction Steps

To a solution of EXAMPLE 22 (1 eq) in THF-MeOH—H2O (2:1:1, 0.1M) was added Oxone (2 eq). The mixture was stirred at rt for 18 h and diluted with water. The residue was isolated by filtration, washed with ether to afford the title compound as a solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07238706B2
Source datasetuspto-grants-2007_07
ORD IDord-c4817dd892fb43f19b6f2f53c2e757ab
Source noteuspto-grants-2007_07