Hydroxyamine hydrochloride → HCID 178516735、化合物

HRID 129443ノート

反応式

HRID 129443 の反応式
[N:1]1[C:2]2[C:14](=O)[C:13]3[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=3[C:3]=2[NH:4][C:5](=[O:7])[CH:6]=1.Cl.[NH2:17][OH:18]>N1C=CC=CC=1>[OH:18][N:17]=[C:14]1[C:2]2[N:1]=[CH:6][C:5](=[O:7])[NH:4][C:3]=2[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:13]1=2

参加物

4

反応物 2

HCID 443297Hydroxyamine hydrochlorideHCID 190359769H-Indeno[1,2-b]pyrazine-3,9(4H)-dione

生成物 1

HCID 178516735HCID 178516735、化合物収率 49%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

反応条件

温度
80 °C

実験手順

A mixture of 9H-indeno[1,2-b]pyrazine-3,9(4H)-dione (1.0 g, 5.0 mmol), pyridine (40 ml) and hydroxylamine hydrochloride (0.42 g, 6.0 mmol) was stirred at 80° C. for 18 hours. The reaction mixture was cooled to room temperature, and the precipitate was filtered off and washed with water, acetic acid and water and dried. The crude material (0.81 g) was recrystallized from DMF to afford 0.52 g (49%) of the title compound. M.p. >300° C. 1H-NMR (DMSO-d6, δ): 7.49-7.62 (m, 2H), 7.88 (d, 1H), 7.95 (s, 1H), 8.36 (d, 1H), 12.5-13.2 (broad, 1H), 12.83 (s, 1H).

後処理

  1. temperatureThe reaction mixture was cooled to room temperature
  2. filtrationthe precipitate was filtered off
  3. washwashed with water, acetic acid and water
  4. customdried
  5. customThe crude material (0.81 g) was recrystallized from DMF

出典と根拠

ORDレコード
ord-b2ba53c1c31a49e8888e0bd501cee82c
出典データセット
uspto-grants-1995_11
特許番号
US05468748

反応ノート

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