2-Chloro-4-methoxypyrimidine → 3-[1-(4-Methoxy-pyrimidin-2-yl)-2-methyl-1H-imidazol-4-ylethynyl]-benzonitrile

HRID 1294502Notes

Reaction equation

HRID 1294502 reaction equation
[CH3:1][C:2]1[NH:3][CH:4]=[C:5]([C:7]#[C:8][C:9]2[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=2)[C:12]#[N:13])[N:6]=1.Cl[C:18]1[N:23]=[C:22]([O:24][CH3:25])[CH:21]=[CH:20][N:19]=1>>[CH3:25][O:24][C:22]1[CH:21]=[CH:20][N:19]=[C:18]([N:3]2[CH:4]=[C:5]([C:7]#[C:8][C:9]3[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=3)[C:12]#[N:13])[N:6]=[C:2]2[CH3:1])[N:23]=1

Participants

3

Reactant 2

HCID 5889352-Chloro-4-methoxypyrimidineHCID 178432699HCID 178432699, compound

Product 1

HCID 114157913-[1-(4-Methoxy-pyrimidin-2-yl)-2-methyl-1H-imidazol-4-ylethynyl]-benzonitrile

Procedure

The title compound, MS: m/e=316.1 (M+H+), was prepared in accordance with the general method of example 1 from 3-(2-methyl-1H-imidazol-4-ylethynyl)-benzonitrile and 2-chloro-4-methoxypyrimidine.

Sources & evidence

ORD record
ord-f68e89358391451b9283ff795cd77616
Source dataset
uspto-grants-2007_07
Patent number
US07241760B2

Reaction notes

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