2,6-Difluoropyridine → 2-[4-[2-(3-Chlorophenyl)ethynyl]-2-methyl-1H-imidazol-1-yl]-6-fluoropyridine

HRID 1294525Notes

Reaction equation

HRID 1294525 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[N:11]=[C:12]([CH3:15])[NH:13][CH:14]=2)[CH:5]=[CH:6][CH:7]=1.[F:16][C:17]1[CH:22]=[CH:21][CH:20]=[C:19](F)[N:18]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[N:11]=[C:12]([CH3:15])[N:13]([C:19]3[CH:20]=[CH:21][CH:22]=[C:17]([F:16])[N:18]=3)[CH:14]=2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 739342,6-DifluoropyridineHCID 178432693HCID 178432693, compound

Product 1

HCID 589062992-[4-[2-(3-Chlorophenyl)ethynyl]-2-methyl-1H-imidazol-1-yl]-6-fluoropyridine

Procedure

The title compound, MS: m/e=312.0, 314.0 (M+H+), was prepared in accordance with the general method of example 1 from 4-(3-chloro-phenylethynyl)-2-methyl-1H-imidazole and 2,6-difluoro-pyridine.

Sources & evidence

ORD record
ord-a34d3d10a58d439faffab349798b239d
Source dataset
uspto-grants-2007_07
Patent number
US07241760B2

Reaction notes

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