Bromine → HCID 22493297, compound

HRID 1294554Notes

Reaction equation

HRID 1294554 reaction equation
[CH3:1][C:2]1[C:11]2[NH:10][C:9](=[O:12])[O:8][C:7](=[O:13])[C:6]=2[CH:5]=[CH:4][CH:3]=1.[Br:14]Br.C(=O)(O)[O-].[Na+]>ClS(O)(=O)=O.[I-].[K+]>[Br:14][C:4]1[CH:3]=[C:2]([CH3:1])[C:11]2[NH:10][C:9](=[O:12])[O:8][C:7](=[O:13])[C:6]=2[CH:5]=1

Participants

6

Reactant 3

HCID 24408BromineHCID 516892Sodium BicarbonateHCID 27598708-methyl-2,4-dihydro-1H-3,1-benzoxazine-2,4-dione

Product 1

HCID 22493297HCID 22493297, compoundYield 155.1%

Reagents, catalysts & solvents 2

HCID 4875Potassium IodideCatalystHCID 24638Chlorosulfonic acidSolvent

Procedure

To a solution of 8-methyl-2H-3,1-benzoxazine-2,4(1H)-dione, (10.0 g, 56.5 mmol) and potassium iodide (0.36 g, 1.8 mmol) in chlorosulfonic acid (12 mL) was added bromine (4.6 g, 28.7 mmol). and the reaction was stirred overnight at room temperature. The reaction was then slowly poured onto ice water and neutralized with sodium bicarbonate powder to a pH of 7. The solids were filtered, rinsed with water and to afford the desired intermediate as a white solid (11.4 g).

Workup

  1. filtrationThe solids were filtered
  2. washrinsed with water

Sources & evidence

ORD record
ord-4d59a76992c242ca8058ba3c2c834931
Source dataset
uspto-grants-2007_07
Patent number
US07241767B2

Reaction notes

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