(2-Amino-6-fluorophenyl)methanol → 2-Amino-6-fluorobenzaldehyde

HRID 1294565Notes

Reaction equation

HRID 1294565 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[CH2:9][OH:10]>C(Cl)(Cl)Cl.[O-2].[Mn+4].[O-2]>[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[CH:9]=[O:10]

Participants

4

Reactant 1

HCID 11521092(2-Amino-6-fluorophenyl)methanol

Product 1

HCID 217194752-Amino-6-fluorobenzaldehyde

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6212ChloroformSolvent

Procedure

1.44 g (10.2 mmol) (2-amino-6-fluoro-phenyl)-methanol are dissolved in 120 ml chloroform, combined with 4.43 g (51 mmol) manganese(IV)-oxide and stirred for 2 days at ambient temperature. Then excess manganese(IV)-oxide is filtered off through Celite and the solvent is eliminated in vacuo.

Workup

  1. filtrationThen excess manganese(IV)-oxide is filtered off through Celite

Sources & evidence

ORD record
ord-b108d51035b343a5afea5c1bd1d77e49
Source dataset
uspto-grants-2007_07
Patent number
US07241769B2

Reaction notes

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