Hydrochloric Acid → (2-Amino-6-fluoro-phenyl)-o-tolyl-methanone

Participants

Reaction Conditions

Reaction Steps

142 mg (0.52 mmol) N-[3-fluoro-2-(2-methyl-benzoyl)-phenyl]-acetamide are dissolved in 2 ml of ethanol, combined with 2 ml of conc. hydrochloric acid and stirred for 4 h at 70° C. Then the reaction mixture is stirred into 30 ml dist. water, adjusted to pH 7 with sodium carbonate and extracted three times with 10 ml of ethyl acetate. Then the organic phase is dried with MgSO4 and the solvent is eliminated in vacuo.

Provenance & Evidence