反应详情

温度

70 °C

142 mg (0.52 mmol) N-[3-fluoro-2-(2-methyl-benzoyl)-phenyl]-acetamide are dissolved in 2 ml of ethanol, combined with 2 ml of conc. hydrochloric acid and stirred for 4 h at 70° C. Then the reaction mixture is stirred into 30 ml dist. water, adjusted to pH 7 with sodium carbonate and extracted three times with 10 ml of ethyl acetate. Then the organic phase is dried with MgSO4 and the solvent is eliminated in vacuo.

1. stirringThen the reaction mixture is stirred into 30 ml dist
2. extractionextracted three times with 10 ml of ethyl acetate
3. dry with materialThen the organic phase is dried with MgSO4