HCID 86093123, compound → 1-[2-(morpholin-4-yl)phenyl]ethan-1-amine

HRID 1294709Notes

Reaction equation

HRID 1294709 reaction equation
CO[N:3]=[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1)[CH3:5]>[Ni].N.CO>[N:12]1([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[CH:4]([NH2:3])[CH3:5])[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1

Participants

5

Reactant 1

HCID 86093123HCID 86093123, compound

Product 1

HCID 431887211-[2-(morpholin-4-yl)phenyl]ethan-1-amineYield 96.3%

Reagents, catalysts & solvents 3

HCID 935NickelCatalystHCID 222AmmoniaSolventHCID 887MethanolSolvent

Procedure

A mixture of Example 49B (1.3 g, 5.54 mmol) and Raney nickel (14 g) in a mixture of 20% NH3 in methanol (140 mL) was hydrogenated at 60 psi for 11 hrs. The reaction was filtered and concentrated to dryness under reduced pressure to give 1.1 g of the title compound. MS (ESI+) m/z 207 (M+H)+.

Workup

  1. filtrationThe reaction was filtered
  2. concentrationconcentrated to dryness under reduced pressure

Sources & evidence

ORD record
ord-6ff2ea89e2c445c69f1d3dc5bdca062c
Source dataset
uspto-grants-2007_07
Patent number
US07241776B2

Reaction notes

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