Hydrochloric Acid → 2-Methyl-5-piperazin-1-yl-benzothiazole hydrochloride

HRID 1294782Notes

Reaction equation

HRID 1294782 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:15]=[CH:16][C:17]3[S:21][C:20]([CH3:22])=[N:19][C:18]=3[CH:23]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:24]>O1CCOCC1>[ClH:24].[CH3:22][C:20]1[S:21][C:17]2[CH:16]=[CH:15][C:14]([N:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)=[CH:23][C:18]=2[N:19]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 589063064-(2-Methyl-benzothiazol-5-yl)-piperazine-1-carboxylic acid tert.-butyl ester

Product 1

HCID 688959552-Methyl-5-piperazin-1-yl-benzothiazole hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Prepared in analogy to example 1.6 (d) from 4-(2-methyl-benzothiazol-5-yl)-piperazine-1-carboxylic acid tert.-butyl ester and dioxane saturated with gaseous hydrochloric acid.

Sources & evidence

ORD record
ord-96540378ae514c5a9028871d26c3c985
Source dataset
uspto-grants-2007_07
Patent number
US07241761B2

Reaction notes

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