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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1294789Generated: October 25, 2026

Hydrochloric Acid → 6-Chloro-2-piperazin-1-yl-quinoline hydrochloride

https://huagongshe.com/reaction/1294789

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantTert-butyl 4-(6-chloroquinolin-2-yl)piperazine-1-carboxylateHCID 58906309—
Solvent1,4-DioxaneHCID 31275—
Product6-Chloro-2-piperazin-1-yl-quinoline hydrochlorideHCID 68896684—

Reaction Steps

Prepared in analogy to example 1.6 (d) from 4-(6-chloro-quinolin-2-yl)-piperazine-1-carboxylic acid tert.-butyl ester and dioxane saturated with gaseous hydrochloric acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07241761B2
Source datasetuspto-grants-2007_07
ORD IDord-9e125a12319b43ec9096866728ad26e0
Source noteuspto-grants-2007_07