Hydrochloric Acid → 6-Chloro-2-piperazin-1-yl-quinoline hydrochloride

HRID 1294789Notes

Reaction equation

HRID 1294789 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:23]=[CH:22][C:21]3[C:16](=[CH:17][CH:18]=[C:19]([Cl:24])[CH:20]=3)[N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>O1CCOCC1>[ClH:24].[Cl:24][C:19]1[CH:20]=[C:21]2[C:16](=[CH:17][CH:18]=1)[N:15]=[C:14]([N:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)[CH:23]=[CH:22]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58906309Tert-butyl 4-(6-chloroquinolin-2-yl)piperazine-1-carboxylate

Product 1

HCID 688966846-Chloro-2-piperazin-1-yl-quinoline hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Prepared in analogy to example 1.6 (d) from 4-(6-chloro-quinolin-2-yl)-piperazine-1-carboxylic acid tert.-butyl ester and dioxane saturated with gaseous hydrochloric acid.

Sources & evidence

ORD record
ord-9e125a12319b43ec9096866728ad26e0
Source dataset
uspto-grants-2007_07
Patent number
US07241761B2

Reaction notes

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