Hydrochloric Acid → 3-Piperazin-1-yl-quinoline hydrochloride

HRID 1294799Notes

Reaction equation

HRID 1294799 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:15]=[N:16][C:17]3[C:22]([CH:23]=2)=[CH:21][CH:20]=[CH:19][CH:18]=3)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:24]>O1CCOCC1>[ClH:24].[N:11]1([C:14]2[CH:15]=[N:16][C:17]3[C:22]([CH:23]=2)=[CH:21][CH:20]=[CH:19][CH:18]=3)[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 589063024-Quinolin-3-yl-piperazine-1-carboxylic acid tert.-butyl ester

Product 1

HCID 688959193-Piperazin-1-yl-quinoline hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Prepared in analogy to example 1.6 (d) from 4-quinolin-3-yl-piperazine-1-carboxylic acid tert.-butyl ester and dioxane saturated with gaseous hydrochloric acid. Yellow solid.

Sources & evidence

ORD record
ord-f2e4ad5b72e54dc78524b094c36904a6
Source dataset
uspto-grants-2007_07
Patent number
US07241761B2

Reaction notes

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