Benzamide, 2-fluoro-N-methoxy-N-methyl-3-(trifluoromethyl)- → (2-Fluoro-3-trifluoromethyl-phenyl)-(4-methoxy-phenyl)-methanone

HRID 1294859Notes

Reaction equation

HRID 1294859 reaction equation
[F:1][C:2]1[C:13]([C:14]([F:17])([F:16])[F:15])=[CH:12][CH:11]=[CH:10][C:3]=1[C:4](N(OC)C)=[O:5].[CH3:18][O:19][C:20]1[CH:25]=[CH:24][C:23]([Mg]Br)=[CH:22][CH:21]=1>>[F:1][C:2]1[C:13]([C:14]([F:15])([F:16])[F:17])=[CH:12][CH:11]=[CH:10][C:3]=1[C:4]([C:23]1[CH:24]=[CH:25][C:20]([O:19][CH3:18])=[CH:21][CH:22]=1)=[O:5]

Participants

3

Reactant 2

HCID 11196047Benzamide, 2-fluoro-N-methoxy-N-methyl-3-(trifluoromethyl)-HCID 178491912HCID 178491912, compound

Product 1

HCID 11231817(2-Fluoro-3-trifluoromethyl-phenyl)-(4-methoxy-phenyl)-methanone

Procedure

Prepared according to Method A step B from 2-fluoro-N-methoxy-N-methyl-3-(trifluoromethyl)benzamide (2.5 g, 10 mmol) and 4-methoxyphenylmagnesium bromide (20 mL, 0.5 M in THF) to give 2.1 g of the title compound as a white solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-5ecc7334745b4779ab621cb927907630
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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