2,3-difluoro-N-methoxy-N-methylbenzamide → (2,3-Difluorophenyl)-(4-methoxy-3-methyl-phenyl)-methanone

HRID 1294866Notes

Reaction equation

HRID 1294866 reaction equation
[F:1][C:2]1[C:13]([F:14])=[CH:12][CH:11]=[CH:10][C:3]=1[C:4](N(OC)C)=[O:5].[CH3:15][O:16][C:17]1[CH:22]=[CH:21][C:20]([Mg]Br)=[CH:19][C:18]=1[CH3:25]>>[F:1][C:2]1[C:13]([F:14])=[CH:12][CH:11]=[CH:10][C:3]=1[C:4]([C:20]1[CH:21]=[CH:22][C:17]([O:16][CH3:15])=[C:18]([CH3:25])[CH:19]=1)=[O:5]

Participants

3

Reactant 2

HCID 626611902,3-difluoro-N-methoxy-N-methylbenzamideHCID 178491913HCID 178491913, compound

Product 1

HCID 55101193(2,3-Difluorophenyl)-(4-methoxy-3-methyl-phenyl)-methanone

Procedure

Prepared according to Method A step B from 2,3-difluoro-N-methoxy-N-methyl-benzamide (2.5 g, 12.4 mmol) and 4-methoxy-3-methyl-phenylmagnesium bromide (26 mL, 0.5 M in THF) to give 0.97 g of the title compound as a white solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-f6a2a6fa2e0945028d75ed3c7ba7ef5b
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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