2-fluoro-N-methoxy-N,3-dimethylbenzamide → (2-Fluoro-3-methylphenyl)(4-methoxy-2-methylphenyl)methanone

HRID 1294868Notes

Reaction equation

HRID 1294868 reaction equation
[F:1][C:2]1[C:13]([CH3:14])=[CH:12][CH:11]=[CH:10][C:3]=1[C:4](N(OC)C)=[O:5].[CH3:15][O:16][C:17]1[CH:22]=[CH:21][C:20]([Mg]Br)=[C:19]([CH3:25])[CH:18]=1>>[F:1][C:2]1[C:13]([CH3:14])=[CH:12][CH:11]=[CH:10][C:3]=1[C:4]([C:20]1[CH:21]=[CH:22][C:17]([O:16][CH3:15])=[CH:18][C:19]=1[CH3:25])=[O:5]

Participants

3

Reactant 2

HCID 807180582-fluoro-N-methoxy-N,3-dimethylbenzamideHCID 178491917HCID 178491917, compound

Product 1

HCID 68883841(2-Fluoro-3-methylphenyl)(4-methoxy-2-methylphenyl)methanone

Procedure

Prepared according to Method A step B from 2- fluoro-3-methyl-N-methoxy-N-methyl-benzamide (3.10 g, 15.7 mmol) and 4-methoxy-2-methyl-phenylmagnesium bromide (40 mL, 0.5 M in THF) to give 1.17 g of the title compound as a white solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-a6798f13e8e949408f279fe6dfaab93a
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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