Benzamide, 2-fluoro-N-methoxy-N-methyl-3-(trifluoromethyl)- → [2-Fluoro-3-(trifluoromethyl)phenyl](4-methoxy-2-methylphenyl)methanone

HRID 1294869Notes

Reaction equation

HRID 1294869 reaction equation
[F:1][C:2]1[C:13]([C:14]([F:17])([F:16])[F:15])=[CH:12][CH:11]=[CH:10][C:3]=1[C:4](N(OC)C)=[O:5].[CH3:18][C:19]1[CH:24]=[C:23]([O:25][CH3:26])[CH:22]=[CH:21][C:20]=1[Mg]Br>>[F:1][C:2]1[C:13]([C:14]([F:15])([F:16])[F:17])=[CH:12][CH:11]=[CH:10][C:3]=1[C:4]([C:20]1[CH:21]=[CH:22][C:23]([O:25][CH3:26])=[CH:24][C:19]=1[CH3:18])=[O:5]

Participants

3

Reactant 2

HCID 11196047Benzamide, 2-fluoro-N-methoxy-N-methyl-3-(trifluoromethyl)-HCID 178491917HCID 178491917, compound

Product 1

HCID 67021619[2-Fluoro-3-(trifluoromethyl)phenyl](4-methoxy-2-methylphenyl)methanone

Procedure

Prepared according to Method A step B from 2- fluoro-3-trifluoromethyl-N-methoxy-N-methylbenzamide (4.05 g, 16.1 mmol) and 2-methyl-4-methoxyphenylmagnesium bromide (42 mL, 0.5 M in THF) to give 1.76 g of the title compound as a white solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-d95fa1a4f79f44289d6c4203c9102582
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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