3-chloro-2-fluoro-N-methoxy-N-methylbenzamide → (3-Chloro-2-fluorophenyl)(2,4-dimethoxyphenyl)methanone

HRID 1294872Notes

Reaction equation

HRID 1294872 reaction equation
[F:1][C:2]1[C:13]([Cl:14])=[CH:12][CH:11]=[CH:10][C:3]=1[C:4](N(OC)C)=[O:5].[CH3:15][O:16][C:17]1[CH:22]=[C:21]([O:23][CH3:24])[CH:20]=[CH:19][C:18]=1[Mg]Br>>[Cl:14][C:13]1[C:2]([F:1])=[C:3]([C:4]([C:20]2[CH:19]=[CH:18][C:17]([O:16][CH3:15])=[CH:22][C:21]=2[O:23][CH3:24])=[O:5])[CH:10]=[CH:11][CH:12]=1

Participants

3

Reactant 2

HCID 114700033-chloro-2-fluoro-N-methoxy-N-methylbenzamideHCID 178491918HCID 178491918, compound

Product 1

HCID 64713965(3-Chloro-2-fluorophenyl)(2,4-dimethoxyphenyl)methanone

Procedure

Prepared according to Method A step B from 2-fluoro-3-chloro-N-methoxy-N-methyl-benzamide (2.44 g, 11.2 mmol) and 2,4-dimethoxyphenylmagnesium bromide (20 mL, 0.5 M in THF) to give 0.95 g of the title compound as a white solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-4c3f0f417fa6450e924c4307967767aa
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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