Cyclohexene → 4-(7-chloro-1-cyclohexyl-1H-indazol-3-yl)phenol

HRID 1294898Notes

Reaction equation

HRID 1294898 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[N:9]([CH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1)[N:8]=[C:7]2[C:17]1[CH:22]=[CH:21][C:20]([O:23]C)=[CH:19][CH:18]=1.B(Br)(Br)Br.C1CCCCC=1>>[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[N:9]([CH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1)[N:8]=[C:7]2[C:17]1[CH:18]=[CH:19][C:20]([OH:23])=[CH:21][CH:22]=1

Participants

4

Reactant 3

HCID 8079CyclohexeneHCID 25134Boron tribromideHCID 688854627-chloro-1-cyclohexyl-3-(4-methoxyphenyl)-1H-indazole

Product 1

HCID 1355252284-(7-chloro-1-cyclohexyl-1H-indazol-3-yl)phenolYield 49.4%

Procedure

Prepared according to Method C step B from 7-chloro-1-cyclohexyl-3-(4-methoxyphenyl)-1H-indazole (0.55 g, 1.61 mmol), boron tribromide (0.61 mL, 6.5 mmol) and 1.0 mL of cyclohexene to give the product (0.26 g) as an off-white solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-ee80b58397114f5eada78a04fff2c41f
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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