4-Bromophenylhydrazine hydrochloride → 1-(4-bromophenyl)-3-(4-methoxyphenyl)-7-trifluoromethyl-1H-indazole

HRID 1294899Notes

Reaction equation

HRID 1294899 reaction equation
F[C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[CH:4][C:3]=1[C:12]([C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=1)=O.Cl.[Br:23][C:24]1[CH:29]=[CH:28][C:27]([NH:30][NH2:31])=[CH:26][CH:25]=1>CN(C1C=CN=CC=1)C>[Br:23][C:24]1[CH:29]=[CH:28][C:27]([N:30]2[C:2]3[C:3](=[CH:4][CH:5]=[CH:6][C:7]=3[C:8]([F:11])([F:10])[F:9])[C:12]([C:14]3[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=3)=[N:31]2)=[CH:26][CH:25]=1

Participants

4

Reactant 2

HCID 121574-Bromophenylhydrazine hydrochlorideHCID 11231817(2-Fluoro-3-trifluoromethyl-phenyl)-(4-methoxy-phenyl)-methanone

Product 1

HCID 688833241-(4-bromophenyl)-3-(4-methoxyphenyl)-7-trifluoromethyl-1H-indazole

Reagents, catalysts & solvents 1

HCID 142844-(Dimethylamino)pyridineCatalyst

Procedure

Prepared according to Method C step A from (2-fluoro-3-trifluoromethyl-phenyl)-(4-methoxyphenyl)-methanone (0.149 g, 0.5 mmol), 4-bromophenylhydrazine hydrochloride (0.134 g, 0.6 mmol) and DMAP (0.061 g, 0.5 mmol) to give the title compound.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-60b6c9b5f6ac4508a799e78c5232ab47
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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