Cyclohexene → 4-[1-cyclohexyl-7-(trifluoromethyl)-1H-indazol-3-yl]phenol

HRID 1294902Notes

Reaction equation

HRID 1294902 reaction equation
[CH:1]1([N:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][C:14]=3[C:16]([F:19])([F:18])[F:17])[C:9]([C:20]3[CH:25]=[CH:24][C:23]([O:26]C)=[CH:22][CH:21]=3)=[N:8]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.B(Br)(Br)Br.C1CCCCC=1>>[CH:1]1([N:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][C:14]=3[C:16]([F:17])([F:18])[F:19])[C:9]([C:20]3[CH:21]=[CH:22][C:23]([OH:26])=[CH:24][CH:25]=3)=[N:8]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 3

HCID 8079CyclohexeneHCID 25134Boron tribromideHCID 688820461-cyclohexyl-3-(4-methoxyphenyl)-7-trifluoromethyl-1H-indazole

Product 1

HCID 1354655954-[1-cyclohexyl-7-(trifluoromethyl)-1H-indazol-3-yl]phenolYield 15.5%

Procedure

Prepared according to Method C step B from 1-cyclohexyl-3-(4-methoxyphenyl)-7-trifluoromethyl-1H-indazole (0.5 mmol), boron tribromide (0.188 mL, 2.0 mmol) and 0.2 mL of cyclohexene to give the product (0.028 g) as a tan solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-aa37159a7b774b27a1fd6af561e543b4
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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