1-Iodopentane → 3-(4-methoxyphenyl)-7-methyl-2-pentyl-2H-indazole

HRID 1294918Notes

Reaction equation

HRID 1294918 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:17]3[C:12](=[C:13]([CH3:18])[CH:14]=[CH:15][CH:16]=3)[NH:11][N:10]=2)=[CH:5][CH:4]=1.[H-].[Na+].I[CH2:22][CH2:23][CH2:24][CH2:25][CH3:26]>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[N:10]([CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[N:11]=[C:12]3[C:17]=2[CH:16]=[CH:15][CH:14]=[C:13]3[CH3:18])=[CH:7][CH:8]=1

Participants

4

Reactant 3

HCID 123351-IodopentaneHCID 24758Sodium hydrideHCID 178489133HCID 178489133, compound

Product 1

HCID 688820493-(4-methoxyphenyl)-7-methyl-2-pentyl-2H-indazoleYield 4.5%

Procedure

Prepared according to Method D step B from 3-(4-methoxyphenyl)-7-methyl-1H-indazole (0.23 g, 1.0 mmol), sodium hydride (60% in oil, 0.048 g, 1.2 mmol) and 1-iodopentane (0.26 mL, 2.0 mmol) to give the title compound (0.014 g). Used as is in the next step.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-972e6261ca6f4181816d46ef6dc1b57b
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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