Isopropyl iodide → 1-isopropyl-3-(4-methoxyphenyl)-7-methyl-1H-indazole

HRID 1294923Notes

Reaction equation

HRID 1294923 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:17]3[C:12](=[C:13]([CH3:18])[CH:14]=[CH:15][CH:16]=3)[NH:11][N:10]=2)=[CH:5][CH:4]=1.[H-].[Na+].I[CH:22]([CH3:24])[CH3:23]>>[CH:22]([N:11]1[C:12]2[C:17](=[CH:16][CH:15]=[CH:14][C:13]=2[CH3:18])[C:9]([C:6]2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=2)=[N:10]1)([CH3:24])[CH3:23]

Participants

4

Reactant 3

HCID 6362Isopropyl iodideHCID 24758Sodium hydrideHCID 178489133HCID 178489133, compound

Product 1

HCID 688843421-isopropyl-3-(4-methoxyphenyl)-7-methyl-1H-indazoleYield 40.7%

Procedure

Prepared according to Method D step B from 3-(4-methoxyphenyl)-7-methyl-1H-indazole (0.115 g, 0.5 mmol), sodium hydride (60% in oil, 0.024 g, 0.6 mmol) and 2-iodopropane (0.10 mL, 1.0 mmol) to give the title compound (0.057 g) as a white solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-7c6794e5cac74406a763ab62f28ce486
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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