1-Iodopentane → 7-chloro-3-(4-methoxyphenyl)-2-pentyl-2H-indazole

HRID 1294929Notes

Reaction equation

HRID 1294929 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][N:8]=[C:7]2[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=1.[H-].[Na+].I[CH2:22][CH2:23][CH2:24][CH2:25][CH3:26]>>[Cl:1][C:2]1[C:10]2[C:6](=[C:7]([C:11]3[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=3)[N:8]([CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[N:9]=2)[CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 123351-IodopentaneHCID 24758Sodium hydrideHCID 178489137HCID 178489137, compound

Product 1

HCID 688859867-chloro-3-(4-methoxyphenyl)-2-pentyl-2H-indazoleYield 9.1%

Procedure

Prepared according to Method D step B from 7-chloro-3-(4-methoxyphenyl)-1H-indazole (0.129 g, 0.5 mmol), sodium hydride (60% in oil, 0.024 g, 0.6 mmol) and 1-iodopentane (0.130 mL, 1.0 mmol) to give the title compound (0.015 g).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-d23499aa0bc149babf55eec5f9f61b29
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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