Isopropyl iodide → HCID 68884529, compound

HRID 1294936Notes

Reaction equation

HRID 1294936 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][N:8]=[C:7]2[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=1.[H-].[Na+].I[CH:22]([CH3:24])[CH3:23]>>[Cl:1][C:2]1[C:10]2[C:6](=[C:7]([C:11]3[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=3)[N:8]([CH:22]([CH3:24])[CH3:23])[N:9]=2)[CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 6362Isopropyl iodideHCID 24758Sodium hydrideHCID 178489137HCID 178489137, compound

Product 1

HCID 68884529HCID 68884529, compoundYield 10.6%

Procedure

Prepared according to Method D step B from 7-chloro-3-(4-methoxyphenyl)-1H-indazole (0.129 g, 0.5 mmol), sodium hydride (60% in oil, 0.024 g, 0.6 mmol) and 2-iodopropane (0.10 mL, 1.0 mmol) to give the title compound (0.016 g).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-179aad8cf29e4e24bf80c15f3983c625
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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