Isopropyl iodide → 3-(4-methoxyphenyl)-1-isopropyl-7-trifluoromethyl-1H-indazole

HRID 1294942Notes

Reaction equation

HRID 1294942 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:17]3[C:12](=[C:13]([C:18]([F:21])([F:20])[F:19])[CH:14]=[CH:15][CH:16]=3)[NH:11][N:10]=2)=[CH:5][CH:4]=1.[H-].[Na+].I[CH:25]([CH3:27])[CH3:26]>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[C:17]3[C:12](=[C:13]([C:18]([F:21])([F:19])[F:20])[CH:14]=[CH:15][CH:16]=3)[N:11]([CH:25]([CH3:27])[CH3:26])[N:10]=2)=[CH:7][CH:8]=1

Participants

4

Reactant 3

HCID 6362Isopropyl iodideHCID 24758Sodium hydrideHCID 178489134HCID 178489134, compound

Product 1

HCID 688838123-(4-methoxyphenyl)-1-isopropyl-7-trifluoromethyl-1H-indazoleYield 25.7%

Procedure

Prepared according to Method D step B from 3-(4-methoxyphenyl)-7-trifluoromethyl-1H-indazole (0.146 g, 0.5 mmol), sodium hydride (60% in oil, 0.024 g, 0.6 mmol) and 2-iodopropane (0.10 mL, 1.0 mmol) to give the title compound (0.043 g) as a white solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-bd733e4c187c42e7bfa69dff2333022d
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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