Allyl bromide → HCID 68885858, compound

HRID 1294944Notes

Reaction equation

HRID 1294944 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][N:8]=[C:7]2[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=1.[H-].[Na+].[CH2:21](Br)[CH:22]=[CH2:23]>>[CH2:23]([N:9]1[C:10]2[C:6](=[CH:5][CH:4]=[CH:3][C:2]=2[F:1])[C:7]([C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=2)=[N:8]1)[CH:22]=[CH2:21]

Participants

4

Reactant 3

HCID 7841Allyl bromideHCID 24758Sodium hydrideHCID 178489142HCID 178489142, compound

Product 1

HCID 68885858HCID 68885858, compoundYield 68.4%

Procedure

Prepared according to Method D step B from 7-fluoro-3-(4-methoxyphenyl)-1H-indazole (0.108 g, 0.44 mmol), sodium hydride (60% in oil, 0.018 g, 0.45 mmol) and allylbromide (0.043 mL, 0.5 mmol) to give the title compound (0.085 g) as a white solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-93128807d78c4917b6d46736c185e7a0
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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