Bromocyclopentane → 7-chloro-1-cyclopentyl-3-(4-methoxyphenyl)-1H-indazole

HRID 1294945Notes

Reaction equation

HRID 1294945 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][N:8]=[C:7]2[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=1.[H-].[Na+].[CH:21]1(Br)[CH2:25][CH2:24][CH2:23][CH2:22]1>>[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[N:9]([CH:21]1[CH2:25][CH2:24][CH2:23][CH2:22]1)[N:8]=[C:7]2[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=1

Participants

4

Reactant 3

HCID 8728BromocyclopentaneHCID 24758Sodium hydrideHCID 178489137HCID 178489137, compound

Product 1

HCID 694319407-chloro-1-cyclopentyl-3-(4-methoxyphenyl)-1H-indazoleYield 49%

Procedure

Prepared according to Method D step B from 7-chloro-3-(4-methoxyphenyl)-1H-indazole (0.129 g, 0.5 mmol), sodium hydride (60% in oil, 0.024 g, 0.6 mmol) and cyclopentylbromide (0.107 mL, 1.0 mmol) to give the title compound (0.080 g) as a white solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-4daac3e3c0284f9c90de809046a762dd
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

Loading…