Allyl bromide → HCID 68884899, compound

HRID 1294956Notes

Reaction equation

HRID 1294956 reaction equation
[CH3:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][N:8]=[C:7]2[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=1.[H-].[Na+].[CH2:21](Br)[CH:22]=[CH2:23]>>[CH2:23]([N:9]1[C:10]2[C:6](=[CH:5][CH:4]=[CH:3][C:2]=2[CH3:1])[C:7]([C:11]2[CH:12]=[CH:13][C:14]([O:17][CH3:18])=[CH:15][CH:16]=2)=[N:8]1)[CH:22]=[CH2:21]

Participants

4

Reactant 3

HCID 7841Allyl bromideHCID 24758Sodium hydrideHCID 178489133HCID 178489133, compound

Product 1

HCID 68884899HCID 68884899, compoundYield 19.4%

Procedure

Prepared according to Method D step B from 7-methyl-3-(4-methoxyphenyl)-1H-indazole (0.112 g, 0.5 mmol), sodium hydride (60% in oil, 0.024 g, 0.6 mmol) and allylbromide (0.086 mL, 1.0 mmol) to give the title compound (0.027 g) as a white solid. Used as is without further characterization.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-0810a5f550ce4be48e94664184575695
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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