Allyl bromide → HCID 68884899, compound

HRID 1294958Notes

Reaction equation

HRID 1294958 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:17]3[C:12](=[C:13]([C:18](F)(F)F)[CH:14]=[CH:15][CH:16]=3)[NH:11][N:10]=2)=[CH:5][CH:4]=1.[H-].[Na+].[CH2:24](Br)[CH:25]=[CH2:26]>>[CH2:26]([N:11]1[C:12]2[C:17](=[CH:16][CH:15]=[CH:14][C:13]=2[CH3:18])[C:9]([C:6]2[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)=[N:10]1)[CH:25]=[CH2:24]

Participants

4

Reactant 3

HCID 7841Allyl bromideHCID 24758Sodium hydrideHCID 178489134HCID 178489134, compound

Product 1

HCID 68884899HCID 68884899, compoundYield 19.4%

Procedure

Prepared according to Method D step B from 3-(4-methoxyphenyl)-7-trifluoromethyl-1H-indazole (0.146 g, 0.5 mmol), sodium hydride (60% in oil, 0.024 g, 0.6 mmol) and allylbromide (0.086 mL, 1.0 mmol) to give the title compound (0.027 g) as a white solid. Used as is without further characterization.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-0a54dd7731014c43bb6c69865a4c4f79
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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