Bromocyclopentane → 1-cyclopentyl-7-fluoro-3-(4-methoxyphenyl)-1H-indazole

HRID 1294962Notes

Reaction equation

HRID 1294962 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][N:8]=[C:7]2[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=1.[H-].[Na+].[CH:21]1(Br)[CH2:25][CH2:24][CH2:23][CH2:22]1>>[CH:21]1([N:9]2[C:10]3[C:6](=[CH:5][CH:4]=[CH:3][C:2]=3[F:1])[C:7]([C:11]3[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=3)=[N:8]2)[CH2:25][CH2:24][CH2:23][CH2:22]1

Participants

4

Reactant 3

HCID 8728BromocyclopentaneHCID 24758Sodium hydrideHCID 178489142HCID 178489142, compound

Product 1

HCID 688843061-cyclopentyl-7-fluoro-3-(4-methoxyphenyl)-1H-indazoleYield 67.8%

Procedure

Prepared according to Method D step B from 7-fluoro-3-(4-methoxyphenyl)-1H-indazole (0.94 g, 3.8 mmol), sodium hydride (60% in oil, 0.148 g, 3.7 mmol) and cyclopentyl-bromide (0.43 mL, 4.0 mmol) to give the title compound (0.80 g) as a white solid,

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-509c722cde5f4388bc5cbc0bc6eba148
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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