Cyclohexene → 4-(1-cyclopentyl-7-fluoro-1H-indazol-3-yl)phenol

HRID 1294963Notes

Reaction equation

HRID 1294963 reaction equation
[CH:1]1([N:6]2[C:14]3[C:9](=[CH:10][CH:11]=[CH:12][C:13]=3[F:15])[C:8]([C:16]3[CH:21]=[CH:20][C:19]([O:22]C)=[CH:18][CH:17]=3)=[N:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.B(Br)(Br)Br.C1CCCCC=1>>[CH:1]1([N:6]2[C:14]3[C:9](=[CH:10][CH:11]=[CH:12][C:13]=3[F:15])[C:8]([C:16]3[CH:17]=[CH:18][C:19]([OH:22])=[CH:20][CH:21]=3)=[N:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 8079CyclohexeneHCID 25134Boron tribromideHCID 688843061-cyclopentyl-7-fluoro-3-(4-methoxyphenyl)-1H-indazole

Product 1

HCID 1355248674-(1-cyclopentyl-7-fluoro-1H-indazol-3-yl)phenolYield 46.1%

Procedure

Prepared according to Method D step C from 1-cyclopentyl-7-fluoro-3-(4-methoxyphenyl)-1H-indazole (0.57 g, 1.83 mmol), boron tribromide (0.70 mL, 7.35 mmol) and 3 mL of cyclohexene to give the product (0.25 g) as a white solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-4e52ee9e55e04aa699672878c4e6ac82
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

Loading…