Cyclohexene → 4-[1-(1-Methylethyl)-7-(trifluoromethyl)-1H-indazol-3-yl]-1,3-benzenediol

HRID 1294970Notes

Reaction equation

HRID 1294970 reaction equation
C[O:2][C:3]1[CH:8]=[C:7]([O:9]C)[CH:6]=[CH:5][C:4]=1[C:11]1[C:19]2[C:14](=[C:15]([C:20]([F:23])([F:22])[F:21])[CH:16]=[CH:17][CH:18]=2)[N:13]([CH:24]([CH3:26])[CH3:25])[N:12]=1.B(Br)(Br)Br.C1CCCCC=1>>[CH:24]([N:13]1[C:14]2[C:19](=[CH:18][CH:17]=[CH:16][C:15]=2[C:20]([F:23])([F:22])[F:21])[C:11]([C:4]2[CH:5]=[CH:6][C:7]([OH:9])=[CH:8][C:3]=2[OH:2])=[N:12]1)([CH3:26])[CH3:25]

Participants

4

Reactant 3

HCID 8079CyclohexeneHCID 25134Boron tribromideHCID 68883776HCID 68883776, compound

Product 1

HCID 1363552294-[1-(1-Methylethyl)-7-(trifluoromethyl)-1H-indazol-3-yl]-1,3-benzenediolYield 66.4%

Procedure

Prepared according to Method D step C from 3-(2,4-dimethoxyphenyl)-1-isopropyl-7-(trifluoromethyl)-1H-indazole (0.442 g, 1.2 mmol), boron tribromide (0.688 mL, 7.27 mmol) and 1.0 mL of cyclohexene to give the product (0.268 g) as an off-white solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-f1d295d4a4584af7b2ffbcdd8e5b02a8
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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