Cyclohexene → 4-[2-allyl-7-(trifluoromethyl)-2H-indazol-3-yl]-3-methylphenol

HRID 1294978Notes

Reaction equation

HRID 1294978 reaction equation
[CH2:1]([N:4]1[C:12]([C:13]2[CH:18]=[CH:17][C:16]([O:19]C)=[CH:15][C:14]=2[CH3:21])=[C:11]2[C:6]([C:7]([C:22]([F:25])([F:24])[F:23])=[CH:8][CH:9]=[CH:10]2)=[N:5]1)[CH:2]=[CH2:3].B(Br)(Br)Br.C1CCCCC=1>>[CH2:1]([N:4]1[C:12]([C:13]2[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][C:14]=2[CH3:21])=[C:11]2[C:6]([C:7]([C:22]([F:25])([F:24])[F:23])=[CH:8][CH:9]=[CH:10]2)=[N:5]1)[CH:2]=[CH2:3]

Participants

4

Reactant 3

HCID 8079CyclohexeneHCID 25134Boron tribromideHCID 688829502-allyl-3-(4-methoxy-2-methylphenyl)-7-(trifluoromethyl)-2H-indazole

Product 1

HCID 1355119444-[2-allyl-7-(trifluoromethyl)-2H-indazol-3-yl]-3-methylphenolYield 80.1%

Procedure

Prepared according to Method D step C from 2-allyl-3-(4-methoxy-2-methylphenyl)-7-(trifluoromethyl)-2H-indazole (0.043 g, 0.124 mmol), boron tribromide (0.05 mL, 0.52 mmol) and 1.0 mL of cyclohexene to give the product (0.033 g) as a white solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-e0608c464de74700b50454a54b3127cd
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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