Cyclohexene → 4-[1-allyl-7-(trifluoromethyl)-1H-indazol-3-yl]-3-methylphenol

HRID 1294982Notes

Reaction equation

HRID 1294982 reaction equation
[CH2:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][C:11]=2[C:13]([F:16])([F:15])[F:14])[C:6]([C:17]2[CH:22]=[CH:21][C:20]([O:23]C)=[CH:19][C:18]=2[CH3:25])=[N:5]1)[CH:2]=[CH2:3].B(Br)(Br)Br.C1CCCCC=1>>[CH2:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][C:11]=2[C:13]([F:16])([F:15])[F:14])[C:6]([C:17]2[CH:22]=[CH:21][C:20]([OH:23])=[CH:19][C:18]=2[CH3:25])=[N:5]1)[CH:2]=[CH2:3]

Participants

4

Reactant 3

HCID 8079CyclohexeneHCID 25134Boron tribromideHCID 688837931-allyl-3-(4-methoxy-2-methylphenyl)-7-(trifluoromethyl)-1H-indazole

Product 1

HCID 1355248844-[1-allyl-7-(trifluoromethyl)-1H-indazol-3-yl]-3-methylphenolYield 117.6%

Procedure

Prepared according to Method D step C from 1-allyl-3-(4-methoxy-2-methylphenyl)-7-(trifluoromethyl)-1H-indazole (0.075 g, 0.22 mmol), boron tribromide (0.082 mL, 0.87 mmol) and 1.0 mL of cyclohexene to give the product (0.086 g) as a white solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-87993599ca7f4026a05d20ccbedf4fb6
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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