Allyl bromide → HCID 57890016, compound

HRID 1294983Notes

Reaction equation

HRID 1294983 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=[CH:5][C:4]=1[C:11]1[C:19]2[C:14](=[C:15]([C:20]([F:23])([F:22])[F:21])[CH:16]=[CH:17][CH:18]=2)[NH:13][N:12]=1.[H-].[Na+].[CH2:26](Br)[CH:27]=[CH2:28]>>[CH2:28]([N:12]1[C:11]([C:4]2[CH:5]=[CH:6][C:7]([O:9][CH3:10])=[CH:8][C:3]=2[O:2][CH3:1])=[C:19]2[C:14]([C:15]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:17]=[CH:18]2)=[N:13]1)[CH:27]=[CH2:26]

Participants

4

Reactant 3

HCID 7841Allyl bromideHCID 24758Sodium hydrideHCID 178489136HCID 178489136, compound

Product 1

HCID 57890016HCID 57890016, compoundYield 34.9%

Procedure

Prepared according to Method D step B from 3-(2,4-dimethoxyphenyl)-7-(trifluoro-methyl)-1H-indazole (0.150 g, 0.49 mmol), sodium hydride (60% in oil, 0.025 g, 1.04 mmol) and allyl bromide (0.07 mL, 0.7 mmol) to give the title compound (0.062 g) as a white solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-b99cf1d51bc54da081528e5ea1d3bc0f
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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