Allyl bromide → HCID 68884982, compound

HRID 1294995Notes

Reaction equation

HRID 1294995 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][N:8]=[C:7]2[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][C:12]=1[CH3:19].[H-].[Na+].[CH2:22](Br)[CH:23]=[CH2:24]>>[CH2:24]([N:9]1[C:10]2[C:6](=[CH:5][CH:4]=[CH:3][C:2]=2[Cl:1])[C:7]([C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][C:12]=2[CH3:19])=[N:8]1)[CH:23]=[CH2:22]

Participants

4

Reactant 3

HCID 7841Allyl bromideHCID 24758Sodium hydrideHCID 178489140HCID 178489140, compound

Product 1

HCID 68884982HCID 68884982, compoundYield 62.7%

Procedure

Prepared according to Method D step B from 7-chloro-3-(4-methoxy-2-methylphenyl)-1H-indazole (0.150 g, 0.52 mmol), sodium hydride (60% in oil, 0.025 g, 1.04 mmol) and allyl bromide (0.07 mL, 0.7 mmol) to give the title compound (0.102 g) as a white solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-b0e7a4fba6824f2ea1e9ea0e50ac5579
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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