Isopropyl iodide → 3-(2,4-dimethoxyphenyl)-7-fluoro-2-isopropyl-2H-indazole

HRID 1295007Notes

Reaction equation

HRID 1295007 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=[CH:5][C:4]=1[C:11]1[C:19]2[C:14](=[C:15]([F:20])[CH:16]=[CH:17][CH:18]=2)[NH:13][N:12]=1.[H-].[Na+].I[CH:24]([CH3:26])[CH3:25]>>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=[CH:5][C:4]=1[C:11]1[N:12]([CH:24]([CH3:26])[CH3:25])[N:13]=[C:14]2[C:19]=1[CH:18]=[CH:17][CH:16]=[C:15]2[F:20]

Participants

4

Reactant 3

HCID 6362Isopropyl iodideHCID 24758Sodium hydrideHCID 1784891453-(2,4-dimethoxyphenyl)-7-fluoro-1H-indazole

Product 1

HCID 688842803-(2,4-dimethoxyphenyl)-7-fluoro-2-isopropyl-2H-indazoleYield 23.1%

Procedure

Prepared according to Method D step B from 3-(2,4-dimethoxyphenyl)-7-fluoro-1H-indazole (0.300 g, 1.10 mmol), sodium hydride (60% in oil, 0.058 g, 1.50 mmol) and 2-iodopropane (0.20 mL, 2.00 mmol) to give the title compound (0.080 g) as a white solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-3bd85efcaddb46ce96a46e5054f55964
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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