Cyclohexene → 4-(7-fluoro-2-isopropyl-2H-indazol-3-yl)benzene-1,3-diol

HRID 1295008Notes

Reaction equation

HRID 1295008 reaction equation
C[O:2][C:3]1[CH:8]=[C:7]([O:9]C)[CH:6]=[CH:5][C:4]=1[C:11]1[N:12]([CH:21]([CH3:23])[CH3:22])[N:13]=[C:14]2[C:19]=1[CH:18]=[CH:17][CH:16]=[C:15]2[F:20].B(Br)(Br)Br.C1CCCCC=1>>[F:20][C:15]1[C:14]2[C:19](=[C:11]([C:4]3[CH:5]=[CH:6][C:7]([OH:9])=[CH:8][C:3]=3[OH:2])[N:12]([CH:21]([CH3:23])[CH3:22])[N:13]=2)[CH:18]=[CH:17][CH:16]=1

Participants

4

Reactant 3

HCID 8079CyclohexeneHCID 25134Boron tribromideHCID 688842803-(2,4-dimethoxyphenyl)-7-fluoro-2-isopropyl-2H-indazole

Product 1

HCID 1363584624-(7-fluoro-2-isopropyl-2H-indazol-3-yl)benzene-1,3-diolYield 36.5%

Procedure

Prepared according to Method D step C from 3-(2,4-dimethoxyphenyl)-7-fluoro-2-isopropyl-2H-indazole (0.07 g, 0.22 mmol), boron tribromide (0.12 mL, 1.2 mmol) and 1.0 mL of cyclohexene to give the product (0.023 g) as a white solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-0f028bdef74f4ebdaaa8271887acccbf
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

Loading…