Isobutyl iodide → HCID 68883805, compound

HRID 1295015Notes

Reaction equation

HRID 1295015 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=[CH:5][C:4]=1[C:11]1[C:19]2[C:14](=[C:15]([F:20])[CH:16]=[CH:17][CH:18]=2)[NH:13][N:12]=1.[H-].[Na+].I[CH2:24][CH:25]([CH3:27])[CH3:26]>>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=[CH:5][C:4]=1[C:11]1[C:19]2[C:14](=[C:15]([F:20])[CH:16]=[CH:17][CH:18]=2)[N:13]([CH2:24][CH:25]([CH3:27])[CH3:26])[N:12]=1

Participants

4

Reactant 3

HCID 10556Isobutyl iodideHCID 24758Sodium hydrideHCID 1784891453-(2,4-dimethoxyphenyl)-7-fluoro-1H-indazole

Product 1

HCID 68883805HCID 68883805, compoundYield 51.8%

Procedure

Prepared according to Method D step B from 3-(2,4-dimethoxyphenyl)-7-fluoro-1H-indazole (0.300 g, 1.10 mmol), sodium hydride (60% in oil, 0.058 g, 1.50 mmol) and 1-iodo-2-methylpropane (0.23 mL, 2.00 mmol) to give the title compound (0.187 g) as a white solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-c64af8eb2bea40cdb3184036865bebe2
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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