Isobutyl iodide → 3-(2,4-dimethoxyphenyl)-7-fluoro-2-isobutyl-2H-indazole

HRID 1295017Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=[CH:5][C:4]=1[C:11]1[C:19]2[C:14](=[C:15]([F:20])[CH:16]=[CH:17][CH:18]=2)[NH:13][N:12]=1.[H-].[Na+].I[CH2:24][CH:25]([CH3:27])[CH3:26]>>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=[CH:5][C:4]=1[C:11]1[N:12]([CH2:24][CH:25]([CH3:27])[CH3:26])[N:13]=[C:14]2[C:19]=1[CH:18]=[CH:17][CH:16]=[C:15]2[F:20]

Participants

Reactant 3

HCID 10556Isobutyl iodide

HCID 24758Sodium hydride

HCID 1784891453-(2,4-dimethoxyphenyl)-7-fluoro-1H-indazole

Product 1

HCID 688841233-(2,4-dimethoxyphenyl)-7-fluoro-2-isobutyl-2H-indazoleYield 12.7%

Procedure

Prepared according to Method D step B from 3-(2,4-dimethoxyphenyl)-7-fluoro-1H-indazole (0.300 g, 1.10 mmol), sodium hydride (60% in oil, 0.058 g, 1.50 mmol) and 1-iodo-2-methylpropane (0.23 mL, 2.00 mmol) to give the title compound (0.046 g) as a white solid.

Workup

customPrepared

Sources & evidence

ORD record: ord-2e559ba1b0434a1c8bdaa68da14f7005
Source dataset: uspto-grants-2007_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07241791B2

Reaction notes

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