Isobutyl iodide → HCID 68885992, compound

HRID 1295019Notes

Reaction equation

HRID 1295019 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][N:8]=[C:7]2[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][C:12]=1[CH3:19].[H-].[Na+].I[CH2:23][CH:24]([CH3:26])[CH3:25]>>[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[N:9]([CH2:23][CH:24]([CH3:26])[CH3:25])[N:8]=[C:7]2[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][C:12]=1[CH3:19]

Participants

4

Reactant 3

HCID 10556Isobutyl iodideHCID 24758Sodium hydrideHCID 178489144HCID 178489144, compound

Product 1

HCID 68885992HCID 68885992, compoundYield 99.8%

Procedure

Prepared according to Method D step B from 7-fluoro-3-(4-methoxy-2-methylphenyl)-1H-indazole (0.300 g, 1.20 mmol), sodium hydride (60% in oil, 0.058 g, 1.50 mmol) and 1-iodo-2-methylpropane (0.23 mL, 2.00 mmol) to give the title compound (0.374 g) as a white solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-90d2a66fe64e470986aac11f53c4f703
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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