Allyl bromide → HCID 68883394, compound

HRID 1295023Notes

Reaction equation

HRID 1295023 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=[CH:5][C:4]=1[C:11]1[C:19]2[C:14](=[C:15]([F:20])[CH:16]=[CH:17][CH:18]=2)[NH:13][N:12]=1.[H-].[Na+].[CH2:23](Br)[CH:24]=[CH2:25]>>[CH2:25]([N:13]1[C:14]2[C:19](=[CH:18][CH:17]=[CH:16][C:15]=2[F:20])[C:11]([C:4]2[CH:5]=[CH:6][C:7]([O:9][CH3:10])=[CH:8][C:3]=2[O:2][CH3:1])=[N:12]1)[CH:24]=[CH2:23]

Participants

4

Reactant 3

HCID 7841Allyl bromideHCID 24758Sodium hydrideHCID 1784891453-(2,4-dimethoxyphenyl)-7-fluoro-1H-indazole

Product 1

HCID 68883394HCID 68883394, compoundYield 57.6%

Procedure

Prepared according to Method D step B from 3-(2,4-dimethoxyphenyl)-7-fluoro-1H-indazole (0.300 g, 1.10 mmol), sodium hydride (60% in oil, 0.058 g, 1.50 mmol) and allyl bromide(0.173 mL, 2.00 mmol) to give the title compound (0.198 g) as a white solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-ede0357e8dd148b2bcba6c2ea04f1081
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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