Boron tribromide → HCID 136358473, compound

HRID 1295031Notes

Reaction equation

HRID 1295031 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[CH:10][CH:11]=[C:12]3[C:16]=2[N:15]([CH2:17][CH2:18][CH3:19])[N:14]=[C:13]3[C:20]2[CH:25]=[CH:24][C:23]([O:26]C)=[CH:22][CH:21]=2)=[CH:4][CH:3]=1.B(Br)(Br)Br>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[CH:10][CH:11]=[C:12]3[C:16]=2[N:15]([CH2:17][CH2:18][CH3:19])[N:14]=[C:13]3[C:20]2[CH:21]=[CH:22][C:23]([OH:26])=[CH:24][CH:25]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 25134Boron tribromideHCID 68886174HCID 68886174, compound

Product 1

HCID 136358473HCID 136358473, compoundYield 72%

Procedure

Prepared according to Method D step C from 7-(4-Fluorophenyl)-3-(4-methoxyphenyl)-1-propyl-1H-indazole (0.125 g, 0.35 mmol), BBr3 (0.066 mL, 0.7 mmol) to give the title compound as a white solid (0.087 g, 0.25 mmol, 72%).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-97ef56600ab74b029ed9ebe29c24374c
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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