3-chloro-2-fluoro-N-methoxy-N-methylbenzamide → (3-Chloro-2-fluorophenyl)(3-fluoro-4-methoxyphenyl)methanone

HRID 1295037Notes

Reaction equation

HRID 1295037 reaction equation
[Cl:1][C:2]1[C:3]([F:14])=[C:4]([CH:11]=[CH:12][CH:13]=1)[C:5](N(OC)C)=[O:6].Br[Mg][C:17]1[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[C:19]([F:25])[CH:18]=1>>[Cl:1][C:2]1[C:3]([F:14])=[C:4]([C:5]([C:17]2[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[C:19]([F:25])[CH:18]=2)=[O:6])[CH:11]=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 114700033-chloro-2-fluoro-N-methoxy-N-methylbenzamideHCID 178491915HCID 178491915, compound

Product 1

HCID 64712239(3-Chloro-2-fluorophenyl)(3-fluoro-4-methoxyphenyl)methanone

Procedure

Prepared according to Method A step B from 3-chloro-2-fluoro-N-methoxy-N-methylbenzamide (4.0 g, 18.4 mmol) and bromo(3-fluoro-4-methoxyphenyl)magnesium (100 mL, 2M in diethyl ether). The title compound was obtained as a white solid (1.65 g, 5.85 mmol, 32%).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-c32623d42b134da6a698b372b2819a7c
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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