Acetyl chloride → HCID 68883476, compound

HRID 1295049Notes

Reaction equation

HRID 1295049 reaction equation
[CH:1]1([N:6]2[C:14]3[C:9](=[CH:10][CH:11]=[CH:12][C:13]=3[F:15])[C:8]([C:16]3[CH:21]=[CH:20][C:19]([OH:22])=[CH:18][CH:17]=3)=[N:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[C:23](Cl)(=[O:25])[CH3:24].C(N(CC)C(C)C)(C)C>>[C:23]([O:22][C:19]1[CH:18]=[CH:17][C:16]([C:8]2[C:9]3[C:14](=[C:13]([F:15])[CH:12]=[CH:11][CH:10]=3)[N:6]([CH:1]3[CH2:5][CH2:4][CH2:3][CH2:2]3)[N:7]=2)=[CH:21][CH:20]=1)(=[O:25])[CH3:24]

Participants

4

Reactant 3

HCID 6367Acetyl chlorideHCID 81531DiisopropylethylamineHCID 1355248674-(1-cyclopentyl-7-fluoro-1H-indazol-3-yl)phenol

Product 1

HCID 68883476HCID 68883476, compound

Procedure

Prepared according to Method E from 4-(1-cyclopentyl-7-fluoro-1H-indazol-3-yl)phenol (0.30 g, 1.0 mmol), acetyl chloride (0.086 mL, 1.2 mmol) and N,N-diisopropylethylamine (0.21 mL, 1.2 mmol) to give 0.31 g to the title compound as a white solid, mp 90–91° C.;

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-41cc69d47a7547d598e486959646bed4
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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