反应详情

A mixture of (3-benzyloxy-1-methyl-1H-pyrazol-4-yl)methanol (18.40 g), active manganese dioxide (40.00 g) and tetrahydrofuran (200 ml) was stirred at room temperature for 9 hrs. Manganese dioxide was filtered off and the filtrate was concentrated. The residue was subjected to silica gel column chromatography, and 3-benzyloxy-1-methyl-1H-pyrazole-4-carbaldehyde (14.80 g, yield 81%) was obtained as a colorless oil from a fraction eluted with ethyl acetate-hexane (2:1, volume ratio).

1. filtrationManganese dioxide was filtered off
2. concentrationthe filtrate was concentrated