反应详情

A mixture of (1-benzyl-3-benzyloxy-1H-pyrazol-4-yl)methanol (14.70 g), active manganese dioxide (30.00 g) and tetrahydrofuran (200 ml) was stirred at room temperature for 2 hrs. Manganese dioxide was filtered off and the filtrate was concentrated. The obtained crystals were collected by filtration to give 1-benzyl-3-benzyloxy-1H-pyrazole-4-carbaldehyde (13.10 g, yield 90%). The crystals were recrystallized from tetrahydrofuran-hexane. melting point: 85–86° C.

1. filtrationManganese dioxide was filtered off
2. concentrationthe filtrate was concentrated
3. filtrationThe obtained crystals were collected by filtration