反应详情

A mixture of ethyl 1-benzyl-3-benzyloxy-1H-pyrazol-4-ylacetate (14.9 g), 5% palladium-carbon (15.0 g), tetrahydrofuran (150 ml) and ethanol (150 ml) was stirred under a hydrogen atmosphere for 2 hrs. Palladium-carbon was filtered off and the filtrate was concentrated to give 1-benzyl-3-hydroxy-1H-pyrazol-4-ylethyl acetate (9.76 g, yield 88%) as colorless crystals. The crystals were recrystallized from tetrahydrofuran-hexane. melting point: 156–157° C.

1. filtrationPalladium-carbon was filtered off
2. concentrationthe filtrate was concentrated